Recombinante rat Groei Hormone R/GHR-eiwit

GHR, also known as growth hormone receptor, is a member of the cytokine receptor superfamily. GHR forms a complex with a tyrosine kinase, suggesting involvement of a ligand-activated tyrosine kinase in intracellular signaling by growth hormone (GH) . Binding of GH to its receptor results in dimerization of the receptor, phosphorylation of the tyrosine kinase JAK2 and of the receptor, followed by a cascade of protein phosphorylations. Recombinant rat GHR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

GHR, GHR/BP

Baculovirus

Rat

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

29.4 kDa (255aa)

Growth Hormone GHR, GHR, GHR/BP, ATGP3305-10 µg, ATGP3305-20 µg, ATGP3305-50 µg, ATGP3305-100 µg, ATGP3305-250 µg, ATGP3305-500 µg, ATGP3305-1 mg, ATGP3305-10, ATGP3305-20, ATGP3305-50, ATGP3305-100, ATGP3305-250, ATGP3305-500, ATGP3305-1

Sobrier ML., et al. (1997) J Clin Endocrinol Metab. 82:435-437.; ; Postel-Vinay MC., et al. (1996) Baillieres Clin Endocrinol Metab. 10:323-336.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Hormones & Cytokines

NP_058790

P16310

Rat

Phe19

FPGSGATPAT LGKASPVLQR INPSLRESSS GKPRFTKCRS PELETFSCYW TEGDDHNLKV PGSIQLYYAR RIAHEWTPEW KECPDYVSAG ANSCYFNSSY TSIWIPYCIK LTTNGDLLKE KCFTVDEIVQ PDPPIGLNWT LLNISLPGIR GDIQVSWQPP PSADVLKGWI ILEYEIQYKE VNETKWKTMS PIWSTSVPLY SLRLDKEHEV RVRSRQRSFE KYSEFSEVLR VTFPQMDTLA ACEEDFRLEH HHHHH