Recombinante rat Lipocaline-2/NGAL-eiwit

Lcn2 also known as Neutrophil gelatinase-associated lipocalin. It belongs to the calycin superfamily and Lipocalin family. It is essential component of the antimicrobial innate immune system, is present in neutrophils and multiple other tissues. It prevents iron acquisition by microorganisms by sequestering iron-loaded bacterial siderophores. In contrast to its pro-apoptotic activity, Lcn2 has also been reported to be a survival factor. Lcn2 protected thyroid carcinoma cells from apoptosis induced by serum deprivation and silencing of Lcn2 reduced thyroid tumor growth. Recombinant rat Lcn2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Neutrophil gelatinase-associated lipocalin

E.coli

Rat

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

> 95% by SDS-PAGE

22.9 kDa (201aa) confirmed by MALDI-TOF

Lipocalin2, NGAL, Neutrophil gelatinase-associated lipocalin, ATGP3168-10 µg, ATGP3168-20 µg, ATGP3168-50 µg, ATGP3168-100 µg, ATGP3168-250 µg, ATGP3168-500 µg, ATGP3168-1 mg, ATGP3168-10, ATGP3168-20, ATGP3168-50, ATGP3168-100, ATGP3168-250, ATGP3168-500, ATGP3168-1

Flo TH., et al. (2004) Nature 432 (7019) :917-21; ; Nasioudis D., et al. (2015) Med Microbiol Immunol. doi.10.1007/s00430-015-0394-1

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Immunology

NP_570097.1

P30152

Rat

QDSTQNL IPAPPLISVP LQPGFWTERF QGRWFVVGLA ANAVQKERQS RFTMYSTIYE LQEDNSYNVT SILVRGQGCR YWIRTFVPSS RPGQFTLGNI HSYPQIQSYD VQVADTDYDQ FAMVFFQKTS ENKQYFKVTL YGRTKGLSDE LKERFVSFAK SLGLKDNNIV FSVPTDQCID N