Recombinante rat UNC5H2/UNC5B-eiwit

UNC5B/UNC5B, also known as Netrin receptor UNC5B, is one of four related receptors that comprise the UNC5 family and serve as receptors for the axon guidance molecule Netrin-1. Outside of the nervous system, UNC5B facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration, as well as Netrin-1-mediated promotion of osteoclast differentiation. Also this protein activates DAPK1 which mediates apoptosis. It is believed to play a role in tumorgenesis. Additionally, It is thought to play a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury. Recombinant Rat UNC5B/UNC5B, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Unc-5 netrin receptor B, Unc5h2, unc-5 homolog 2, Protein unc-5 homolog B, netrin receptor UNC5B precursor, netrin receptor UNC5B, protein unc-5 homolog 2, unc5b

HEK293

Rat

HIgG-His-Tag

SDS-PAGE

0.25 mg/mL (determined by Absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

66.0kDa (590aa)

, ATGP3950-10 µg, ATGP3950-20 µg, ATGP3950-50 µg, ATGP3950-100 µg, ATGP3950-250 µg, ATGP3950-500 µg, ATGP3950-1 mg, ATGP3950-10, ATGP3950-20, ATGP3950-50, ATGP3950-100, ATGP3950-250, ATGP3950-500, ATGP3950-1

Bhat SA, et al, (2019) J Cell Commun Signal. 13:121-127.; ; Mediero A, et al, (2016) FASEB J. 30:3835-3844.; ; Liu J, et al, (2013) Tumour Biol. 34:2099-2108.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_071543

O08722

Rat

Asp

GIDSGG QALPDSFPSA PAEQLPHFLL EPEDAYIVKN KPVELHCRAF PATQIYFKCN GEWVSQKGHV TQESLDEATG LRIREVQIEV SRQQVEELFG LEDYWCQCVA WSSSGTTKSR RAYIRIAYLR KNFDQEPLAK EVPLDHEVLL QCRPPEGVPV AEVEWLKNED VIDPAQDTNF LLTIDHNLII RQARLSDTAN YTCVAKNIVA KRRSTTATVI VYVNGGWSSW AEWSPCSNRC GRGWQKRTRT CTNPAPLNGG AFCEGQACQK TACTTVCPVD GAWTEWSKWS ACSTECAHWR SRECMAPPPQ NGGRDCSGTL LDSKNCTDGL CVLNQRTLND PKSRPLEPSG D