Recombinatie 53BP1 monoklonaal antilichaam

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V (D) J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

53BP1

Q12888

Human

Recombinant Human 53BP1 protein

53BP; TDRD; tumor protein p53 binding protein; p53BP; TP53BP; TP53BP1;53BP1; TDRD30; TP53; p202; p53BP1; tumor protein p53 binding protein 1;53BP1; p202; p53BP1; TDRD30; TP53; tumor protein p53 binding protein 1

5F5

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling; Cancer

Protein A

0.2 mg/mL

WB 1:2000-1:10000; IHC 1:200-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/0XiEIbrQ

214 kDa

450 kDa

IgG, κ