Recombinatie AKT1 monoklonaal antilichaam

The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

AKT1

P31749

Human; Rat; Mouse

Recombinant human AKT1 fragment

CWS; MGC; AKT serine/threonine kinase; AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA; AKT1; AKT 1; AKT serine/threonine kinase 1; AKT1_HUMAN; MGC99656; Protein kinase B; Protein Kinase B Alpha; Proto-oncogene c-Akt; RAC Alpha; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; AKT; AKT serine/threonine kinase 1; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA

A123

Unconjugated

WB; IHC

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Metabolism; Neuroscience

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/wIwlon5q

60 kDa

60 kDa

IgG, κ