Recombinatie APAF1 monoklonaal antilichaam

Apoptotic protease activating factor 1 (Apaf-1), originally identified as the mammalian homolog of the C. elegans apoptotic regulatory protein CED-4, is an important signaling protein involved in the activation of caspase-9 during apoptosis. Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. The protein contains an amino-terminal CARD domain, a central CED-4 homology domain, and multiple WD-40 repeats at the carboxy terminus. Several isoforms of Apaf-1 are expressed through alternative splicing generating a small insert following the CARD domain as well as an extra WD-40 repeat. Apaf-1 knock-out mice display widespread defects in apoptosis and resistance to a variety of apoptotic stimuli.

APAF1

O14727

Human; Rat; Mouse

Peptide. This information is proprietary to PTMab.

KIAA; Apoptotic protease-activating factor; Apoptotic peptidase activating factor; CED; APAF1; APAF-1; CED4; APAF; APAF 1; Apoptotic peptidase activating factor 1; Apoptotic protease activating factor; Apoptotic protease activating factor 1; Apoptotic protease-activating factor 1; CED 4; KIAA0413

A709

Unconjugated

WB; IHC

Cell Biology; Cancer; Metabolism

Protein A purified

1 mg/mL

WB 1:1000-1:3000; IHC 1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/CfQE5cqw

142 kDa

140 kDa

IgG, κ