Recombinatie ASGPR1 / ASGR1 monoklonaal antilichaam

The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR) . ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1 (MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2) . ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

ASGR1

P34927

Mouse

Recombinant Mouse ASGPR1/ASGR1 protein

Asgr-1; Asgr1; ASGPR1; Asgr; HL-1

9B10

Unconjugated

IHC-P

Protein A

1 mg/mL

IHC-P 1:250-1:1000

0.2 μm filtered solution in PBS

Ice bag

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

https://789.bio/eb/reJyrP0T

IgG