Recombinatie BCL6 monoklonaal antilichaam

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

BCL6

P41182

Human

Recombinant human BCL6 fragment

ZNF; LAZ; ZBTB; BCL; BCL6; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51

A139

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling; Cancer

Protein A purified

1 mg/mL

WB 1:1000-1:5000; IHC 1:100-1:500

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/hdxRwNO9

79 kDa

78 kDa

IgG, κ