Recombinatie Calmoduline 1 / 2 / 3

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calmodulin (CaM) is a ubiquitously expressed Ca2+ binding protein best known for its ability to activate CaM-dependent kinases in a variety of cells. It was initially identified in its role as an activator of cAMP PDE. In fact, calmodulin was first known as the calcium-dependent regulator protein of PDE. Calmodulin is involved, directly and indirectly, in modulation of several ion channels, including Na+, K+, L-type Ca2+, and RYR2 channels. The main binding partner of calmodulin in cardiac cells is RyR2, which regulates Ca2+ release from the sarcoplasmic reticulum. Acting as an intracellular Ca2+ sensor, Ca2+-saturated calmodulin binds RYR2 to inhibit Ca2+ release by stabilizing the RyR2 channel closed state.

Calmodulin 1/2/3

P0DP23; P0DP24; P0DP25

Human; Rat; Mouse

Recombinant human Calmodulin 1/2/3 fragment

CALM1; CALM2; CALM3

A439

Unconjugated

WB

Protein A purified

1 mg/mL

WB 1:1000-1:5000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/FKWHw1kp

17 kDa

17 kDa

IgG, κ