Recombinatie CD146 monoklonaal antilichaam

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration., similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains., similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., tissue specificity:Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

CD146

P43121

Human; Mouse; Rat

Recombinant Human CD146 protein

MUC; cell surface glycoprotein MUC; MCAM; CD146; MUC18; cell surface glycoprotein MUC18; S-endo; MCAM; Mel-CAM; Endo-CAM; CD146; cell surface glycoprotein MUC18; MUC18; A32 antigen; CD 146; CD146 antigen; Cell surface glycoprotein P1H12; Gicerin; Melanoma adhesion molecule; Melanoma associated antigen A32; Melanoma associated antigen MUC18; Melanoma associated glycoprotein MUC18; melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; MelCAM; MUC 18; S endo 1; S endo 1 endothelial associated antigen; S-endo 1 endothelial-associated antigen

4D3

Unconjugated

WB; IHC

Immunology; Signal Transduction; Cancer; Stem Cells; Cardiovascular

Protein A

0.2 mg/mL

IHC 1:1000-1:4000; WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/FdRAVA9D

72 kDa

125 kDa

IgG, κ