Recombinatie CD39 monoklonaal antilichaam

CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), is a multi-pass membrane ectoenzyme that metabolizes adenosine-5'-triphosphate (ATP) to regulate purinergic signaling. Purinergic signaling by extracellular ATP and its metabolites regulate many biological processes, including vascular tone, digestion, neuronal function, and inflammation in both normal and diseased states. CD39 is expressed in endothelial cells in the vasculature to regulate local platelet purinergic signaling via metabolism of ATP to adenosine. Accordingly, CD39 regulates platelet activation aggregation and contributes to the antithrombotic properties of endothelial cells. ATP and its metabolites also finely modulate the activity of T cells and macrophages. Immunomodulation is regulated, in part, by the availability of extracellular ATP and adenosine, suggesting that CD39 may play an immunosuppressive role in the tumor microenvironment.

CD39

P49961

Human; Mouse

Recombinant fragment

SPG; Ecto-ATP diphosphohydrolase; Ectonucleoside triphosphate diphosphohydrolase; ENTPD; ENTPD1; ATPDase; CD39; NTPDase-1; SPG64; CD 39; NTPDase1; Ecto-apyrase; Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Lymphoid cell activation antigen; NTPDase-1; CD39 antigen; DKFZp686D194; DKFZp686I093; Ecto apyrase; Ecto ATP diphosphohydrolase; Ecto-ATPase 1; Ecto-ATPDase 1; ENTP1; ENTPD 1; FLJ40921; FLJ40959

A701

Unconjugated

WB

Immunology

Protein A purified

1 mg/mL

WB 1:1000-1:2000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/dihWPSUH

58 kDa

78 kDa

IgG, κ