Recombinatie CD3G monoklonaal antilichaam

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.

CD3G

P09693

Human

Recombinant human CD3G fragment

T3G; CD3G; T3; CD_antigen: CD3g; CD3g molecule; CD3-GAMMA; IMD17; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain

A172

Unconjugated

WB; IHC; IF; IP

Immunology; Stem Cells

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:500-1:2000; IF 1:50; IP 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/7LxW8tUN

20 kDa

18-28 kDa

IgG, κ