Recombinatie Cdc25C monoklonaal antilichaam

Cdc25C is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis. Cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint. When phosphorylated at Ser216, Cdc25C binds to members of the 14-3-3 family of proteins, sequestering Cdc25C in the cytoplasm and thereby preventing premature mitosis. The checkpoint kinases Chk1 and Chk2 phosphorylate Cdc25C at Ser216 in response to DNA damage.

Cdc25C

P30307

Human; Rat; Mouse

Recombinant human Cdc25C fragment

CDC; PPP1R; CDC25C; CDC25; PPP1R60

A595

Unconjugated

WB

Cell Biology; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:500-1:2000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/uLJgdS7g

53 kDa

53 kDa

IgG, κ