Recombinatie CDK8 monoklonaal antilichaam

Cyclin-dependent kinase 8 (CDK8) is a cell cycle regulator, which can activate cyclin C, act in the G1/S phase, and regulate the normal cell cycle. CDK8 together with Cyclin, Med12 and Med13 form an intermediary complex, which is widely involved in the transmission of information between RNA polymerase II and gene-specific transcription factors, which can activate and inhibit transcription. In addition, CDK8 can activate a variety of signal transduction pathways such as Wnt/β-catenin and Notch, thereby inducing the occurrence and metastasis of malignant tumors such as rectal cancer and melanoma. Recent studies have found that blocking the activity of CDK8 gene can greatly reduce the glucose utilization rate of cancer cells.

CDK8

P49336

Human; Mouse

Recombinant human CDk8 fragment

CDK; CDK8; K35; Cell division protein kinase 8

A183

Unconjugated

WB; IHC

Cell Biology; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/s9M8Xdsk

53 kDa

53 kDa

IgG, κ