Recombinatie CHD4 monoklonaal antilichaam

Chromodomain helicase DNA-binding protein 4 (CHD4) is an ATP dependent chromatin remodeler and a major subunit of the repressive NuRD complex. This complex plays key roles in transcriptional regulation and reorganization and maintenance of chromatin structure, as it targets pericentromeric heterochromatin and has recently been implicated in DNA damage repair, being rapidly recruited to DNA double strand breaks. CHD4 is a novel BRIT1 binding partner that regulates the HR repair process, which is a critical pathway of repairing DNA double strand breaks and plays an essential role in maintaining genomic integrity. The calculated molecular weight of CHD4 is 218 kDa, but modified CHD4 is about 250-280 kDa.

CHD4

Q14839

Human; Rat; Mouse

Recombinant human CHD4 fragment

CHD; CHD4; CHD-4; Mi-2b; Mi2-BETA; SIHIWES

A649

Unconjugated

WB; IHC

Immunology; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:1000-3000; IHC 1:50-100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/QDdLW6t0

218 kDa

280 kDa

IgG, κ