Recombinatie CTCF monoklonaal antilichaam

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT) -containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC) -containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.

CTCF

P49711

Human; Mouse; Rat

Recombinant Human CTCF protein

MRD; Cancer/testis antigen; CTCF; MRD21;11-Zinc Finger Protein; BORIS; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC-Binding Factor; CT27; CTCF paralog; CTCFL; CTCFL Paralog; CTCF-like protein; Transcriptional Repressor CTCF; Transcriptional repressor CTCFL; Zinc finger protein CTCF-T

12G4

Unconjugated

WB

Epigenetics and Nuclear Signaling

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/9aFYY2Gd

83 kDa

140 kDa

IgG, κ