Recombinatie DcR1 monoklonaal antilichaam

The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems.The receptors are activated by a family of cytokines that include TNF, FasL, and TNF-related apoptosis-inducing ligand (TRAIL) . They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD) . The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2, and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.

DcR1

O14798

Human

Peptide. This information is proprietary to PTMab.

DCR; UNQ; PRO; TRAILR; TRAIL-R; TNFRSF10C; CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID; UNQ321; PRO366; DcR1; TRID; TNFRSF10c; Antagonist Decoy Receptor for TRAIL/Apo-2L; Decoy Receptor 1; Decoy TRAIL Receptor Without Death Domain; Lymphocyte Inhibitor of TRAIL; TNF-Related Apoptosis-Inducing Ligand Receptor 3; TRAIL Receptor 3; TRAIL Receptor Without an Intracellular Domain; Tumor Necrosis Factor Receptor Superfamily Member 10C

A716

Unconjugated

WB; IF

Cell Biology; Immunology; Cancer

Protein A purified

1 mg/mL

WB 1:1000-1:2000; IF 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/zMnkwhfP

27 kDa

27, 80-100 kDa

IgG, κ