Recombinatie DDB2 monoklonaal antilichaam

Damaged DNA-Binding Protein (DDB) consists of a 127 kDa subunit (DDB-1) and a 48 kDa subunit (DDB-2) that contribute to the formation of the UV-damaged DNA-binding protein complex (UV-DDB) . In conjunction with CUL4A and ROC-1, the UV-DDB complex forms an E3 ubiquitin ligase that recognizes a broad spectrum of DNA lesions such as cyclobutane pyrimidine dimers, 6-4 photoproducts, apurinic sites and short mismatches. The complex polyubiquitinates components of the nucleotide excision repair pathway. Loss of DDB activity has been identified in a subset of xeroderma pigmentosum complementation group E (XP-E) patients and has been linked to the deficient repair of cyclobutane pyrimidine dimers in cells derived from these patients.

DDB2

Q92466

Human

Recombinant human DDB2 fragment

DDB; UV-DDB; DDB2; DDBB; UV-DDB2; XPE

A636

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling; Cancer

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:500-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/EvVCDuPg

48 kDa

48 kDa

IgG, κ