Recombinatie DR5 monoklonaal antilichaam

DR5, also known as CD262, TNFRSF10B, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF) . It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells. DR5 contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which DR5 is capable to transmit the apoptotic signal. In PDAC cells, especially Panc89 cells, it expresses additionally to the approximately 48 and 40 kDa forms of DR5, a faster migrating variant of DR5 of about 32 kDa. The TRAIL receptor 2 (death receptor 5, or DR5) forms receptor dimers in a ligand-dependent manner.

DR5

O14763

Human

Recombinant human DR5 fragment

UNQ; PRO; Death Receptor; TRAIL Receptor; TNF-Related Apoptosis-Inducing Ligand Receptor; TRICK; ZTNFR; TRAILR; TRAIL-R; KILLER/DR; CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9; TNFRSF10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; Tumor Necrosis Factor Receptor Superfamily Member 10B; UNQ160; PRO186; DR5; KILLER; TNFRSF10b

A568

Unconjugated

WB; IHC

Cell Biology; Signal Transduction; Cancer; Cardiovascular

Protein A purified

1 mg/mL

WB 1:1000-1:5000; IHC 1:200-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/xZBL09bV

48 kDa

40,48 kDa

IgG, κ