Recombinatie EAAT3 monoklonaal antilichaam

During neurotransmission, glutamate is released from vesicles of the presynaptic cell, and glutamate receptors (e.g., NMDA Receptor, AMPA Receptor) bind glutamate for activation at the opposing postsynaptic cell. Excitatory amino acid transporters (EAATs) regulate and maintain extracellular glutamate concentrations below excitotoxic levels. In addition, glutamate transporters may limit the duration of synaptic excitation by an electrogenic process in which the transmitter is cotransported with three sodium ions and one proton, followed by countertransport of a potassium ion. Five EAATs (EAAT1-5) have been identified. EAAT1 and EAAT2 are expressed mainly in glia, while EAAT3, EAAT4, and EAAT5 are considered to be neuronal transporters. EAAT3 is found in the perisynaptic areas and cell bodies of glutamatergic and GABAergic neurons. Research studies have implicated abnormal EAAT3 expression in the pathophysiology of Schizophrenia.

EAAT3

P43005

Human

Peptide. This information is proprietary to PTMab.

EAAC; EAAT; SCZD; SLC1A; SLC1A1; DCBXA; EAAC1; EAAT3; SCZD18; EAA3; EAAC 1; EAAT 3; Excitatory amino acid carrier 1; Excitatory amino acid carrier1; Excitatory amino acid transporter 3; Excitatory amino acid transporter3; Excitatory amino-acid carrier 1; GLUTAMATE TRANSPORTER; HIGH-AFFINITY; MEAAC 1; MEAAC1; member 1; Neuronal and epithelial glutamate transporter; REAAC 1; REAAC1; Slc1 a1; Slc1a 1; Sodium dependent glutamate/aspartate transporter 3; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1; Solute carrier family 1 (neuronal / epithelial high affinity glutamate transporter; Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter; SOLUTE CARRIER FAMILY 1 (NEURONAL/EPITHELIAL HIGH AFFINITY GLUTAMATE TRANSPORTER) ; Solute carrier family 1 member 1; system Xag)

A729

Unconjugated

WB; IHC

Neuroscience

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:500-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/a8y3ySIh

57 kDa

70 kDa

IgG, κ