Recombinatie EGR2- monoklonaal antilichaam

EGR2 is also named as KROX20, belongs to the EGR C2H2-type zinc-finger protein family. As a zinc finger transcription factor, it is observed in both the somata and dendrites of central neurons. EGR2 plays an important role in the transient formation of hindbrain developmental compartments or rhombomeres and is also an important factor in peripheral myelination, maintenance of synaptic plasticity and long-term potentiation. EGR2 expression is induced downstream of TCR signaling in NKT precursors and EGR2 is directly connected with the key molecular checkpoints defining NKT lineage commitment and stage progression, suggesting that EGR2 not only induces the early lineage-defining transcription factor PLZF, but also controls the downstream expression of the IL-2Rβ chain. EGR2 is regulated by both soluble and membrane-bound neuregulins and its concentration is partially modulated by calcium-dependent events. EGR2/Krox20 is also required for induction of Pmp22, and is nuclear-localized.

EGR2

P11161

Human; Rat; Mouse

Peptide. This information is proprietary to PTMab.

EGR; KROX; EGR2; AT591; CMT1D; CMT4E; KROX20; DKFZp686J1957; Drosophila; E3 SUMO-protein ligase EGR2; early growth response 2; Early growth response protein 2; EGR-2; FLJ14547; homolog (early growth response-2) ; KROX 20 Drosophila homolog; Krox 20 homolog Drosophila; KROX-20; Krox20 protein; Zinc finger protein Krox-20

A776

Unconjugated

WB

Epigenetics and Nuclear Signaling; Neuroscience

Protein A purified

1 mg/mL

WB 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/Kjy0O3Za

50 kDa

55 kDa

IgG, κ