Recombinatie-ERG monoklonaal antilichaam

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.

ERG

P11308

Human; Mouse; Rat

Recombinant Human ERG protein

ERG; Avian erythroblastosis virus E-26 (v-ets) oncogene related; D030036I24Rik; Erg 3; ERG/EWS fusion gene; ERG/FUS fusion gene; ERG/TMPSSR2 fusion gene; ERG1; ERG2; ets related; ETS-related gene; included; isoform CRA_e; KCNH2; Oncogene ERG; p55; TMPRSS2/ERG fusion; Transcriptional regulator ERG; transcriptional regulator ERG (transforming protein ERG) ; Transforming protein ERG; v ets avian erythroblastosis virus E26 oncogene; v ets avian erythroblastosis virus E26 oncogene related; v ets erythroblastosis virus E26 oncogene homolog; v ets erythroblastosis virus E26 oncogene like; v ets erythroblastosis virus E26 oncogene like isoform 2; v-ets erythroblastosis virus E26 oncogene; v-ets erythroblastosis virus E26 oncogene homolog (avian) ; V-ets erythroblastosis virus E26 oncogene like (Avian)

11A6

Unconjugated

WB

Epigenetics and Nuclear Signaling; Stem Cells

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/6C5oFa0Q

55 kDa

55 kDa

IgG, κ