Recombinatie FEN1 monoklonaal antilichaam

Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double-stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.

FEN1

P39748

Human; Rat

Recombinant human FEN1 fragment

RAD; FEN; FEN1; FEN-1; MF1; RAD2

A638

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:200-1:500

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/qFqa3lcW

43 kDa

43 kDa

IgG, κ