Recombinatie GABA B Ontvanger 1 Multiklonale Antilichaam

GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA (A), GABA (B) and GABA (C) receptor. The metabotropic GABA (B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission. Functional GABA (B) receptors form heterodimers of GABA (B) R1 and GABA (B) R2 where GABA (B) R1 binds the ligand and GABA (B) R2 is the primary G protein contact site. GABA (B) R1 has two isoforms: GABA (B) R1a and GABA (B) R1b. GABA (B) R1a is a 130 kD protein and GABA (B) R1b is a 95 kD protein. G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA (B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA (B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA (B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA (B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation.

GABA B Receptor 1

Q9UBS5

Rat; Mouse

Recombinant human GABA B Receptor 1 fragment

GABBR; GABABR; GABBR1; GABABR1; GABBR1-3; GB1; GPRC3A

A650

Unconjugated

WB; IHC

Neuroscience

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:200-1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/e08x0xSI

108 kDa

108 kDa

IgG, κ