Recombinatie GRK2 monoklonaal antilichaam

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO) -dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light.

GRK2

P25098

Human; Rat; Mouse

Recombinant human GRK2 fragment

GRK; Adrenergic beta receptor kinase; Beta adrenergic receptor kinase; Beta-adrenergic receptor kinase; G protein coupled receptor kinase; G-protein coupled receptor kinase; ARBK; ADRBK; GRK2; ADRBK1; BARK1; BETA-ARK1; Adrenergic beta receptor kinase 1; ARBK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; FLJ16718; G protein coupled receptor kinase 2; G-protein coupled receptor kinase 2; BARK

A240

Unconjugated

WB; IF

Neuroscience; Signal Transduction

Protein A purified

1 mg/mL

WB 1:1000-1:5000; IF 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/Prt8z9bw

80 kDa

80 kDa

IgG, κ