Recombinatie HMGB2- monoklonaal antilichaam

HMGB2 belongs to a family of highly conserved proteins that contain HMG box domains. HMGB2 is widely expressed during embryonic development, but it is restricted to lymphoid organs and testis in adult animals. HMGB2 facilitate the binding of Hox proteins, Oct proteins, p53, Rel proteins, and steroid hormone receptor proteins to their target gene promoters. Furthermore, HMGB2 interacts with RAG1 to facilitate RAG complex binding to the recombinant signal sequence (RSS) and stimulate DNA-bending and subsequent VDJ cleavage at antigen receptor genes. In addition to their functions in the nucleus, HMGB proteins play a significant role in extracellular signaling associated with inflammation. HMGB2 is secreted by myeloid cells and promotes proliferation and migration of endothelial cells by binding to the receptor for advanced glycation end products (RAGE) .

HMGB2

P26583

Human; Rat; Mouse

Recombinant human HMGB2 fragment

HMGB; High mobility group box; High mobility group (nonhistone chromosomal) protein; HMG B; HMG; HMGB2; HMG2; C80539; High mobility group (nonhistone chromosomal) protein 2; High mobility group box 2; High mobility group protein 2; High mobility group protein B2; HMG 2; HMG B2; HMG-2

A533

Unconjugated

WB; IHC; IF; IP

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:50-1:100; IF 1:50; IP 1:25-1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/3VmvwbUY

24 kDa

24 kDa

IgG, κ