Recombinatie HMGCR monoklonaal antilichaam

3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein of the endoplasmic reticulum. It is the rate-limiting enzyme for cholesterol biosynthesis and non-sterol isoprenoid biosynthesis. Play a key role in cellular cholesterol homeostasis. The activity of HMGCR is regulated by negative feedback, in which cholesterol and other end products of the metabolic pathway inhibit the activity of HMGCR in a multivalent manner. Cholesterol inhibits reductase activity mainly by inhibiting the transcription rate of HMGCR gene. HMGCR is the main target of statins, which are a class of cholesterol-lowering drugs.

HMGCR

P04035

Human; Mouse

Recombinant human HMG-CoA Reductase fragment

LDLCQ; HMGCR; LDLCQ3;3-hydroxy-3-methylglutaryl-CoA reductase;3-hydroxy-3-methylglutaryl-CoA reductase; LDLCQ3;3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase

A254

Unconjugated

WB; IF; FCM; IP

Cardiovascular; Signal Transduction; Cancer; Metabolism

Protein A purified

1 mg/mL

WB 1:500-1:2000; IF 1:50; FCM 1:50-1:100; IP 1:25

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/6rZ4TEhA

97 kDa

97 kDa

IgG, κ