Recombinatie JMJD2D monoklonaal antilichaam

JMJD2D (KDM4D) is a histone demethylase located in the nucleus that specifically demethylates Lysine 9 of Histone H3, thereby playing a central role in the histone code. JMJD2D (KDM4D) demethylates both di- and trimethylated histone H3 Lys 9, while it has no activity on monomethylated residues. The demethylation reaction of the Lys residue generates formaldehyde and succinate as a by product. In addition, JMJD2D forms a complex with the ligand-bound form of the Androgen Receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D (KDM4D) may be involved in carcinogenesis.

JMJD2D

Q6B0I6

Human

Peptide. This information is proprietary to PTMab.

JHD3D; JmjC domain-containing histone demethylation protein 3D; Jumonji domain-containing protein 2D; Lysine-specific demethylase 4D; JHDM3D; JMJD2D; KDM4D

A738

Unconjugated

WB

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/oRbW2VV2

59 kDa

65 kDa

IgG, κ