Recombinatie MASH1 monoklonaal antilichaam

MASH1, also known as achaete-scute homolog 1 (ASCL1), is a basic helix-loop-helix (BHLH) transcription factor which plays an essential role in the differentiation of neuroendocrine cells and neural tissues. MASH1 directly binds the E-box motif (5'-CANNTG-3') on promoters, with dimerization with other BHLH proteins required for efficient DNA binding. Acting as a pioneer transcription factor, MASH1 also accesses closed chromatin, allowing other factors to promote transcription of neuronal genes and activate neural pathways. Research studies have shown that knockdown of the MASH1 gene leads to inhibition of growth and induction of apoptosis in SCLC cells in vitro. Additionally, MASH1 is overexpressed in both classic SCLC as well as NSCLC with neuroendocrine features, suggesting its role in the pathogenesis of those malignancies. MASH1 plays a crucial role in promoting SCLC carcinogenesis by upregulating the expression of DLL3, a nonfunctioning Notch ligand, leading to inhibition of the Notch signaling pathway.

MASH1

P50553

Human

Peptide. This information is proprietary to PTMab

ASH; ASCL; HASH; MASH; bHLHa; ASCL1; ASH1; HASH1; MASH1; bHLHa46; Achaete scute complex homolog 1; Achaete scute complex homolog like 1; Achaete scute complex homologue 1; Achaete scute complex homologue like 1; Achaete scute complex like 1; Achaete scute family bHLH transcription factor 1; Achaete scute protein; Achaete-scute homolog 1; Ascl 1; Ash 1; ASH-1; Class A basic helix-loop-helix protein 46; Hash 1; Mammalian achaete scute homolog 1; Mammalian achaete scute homologue 1; Mash 1

A718

Unconjugated

WB

Epigenetics and Nuclear Signaling; Neuroscience

Protein A purified

1 mg/mL

WB 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/vRy4AyVh

25 kDa

30 kDa

IgG, κ