Recombinatie MECPC 2 monoklonaal antilichaam

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

MeCP2

P51608

Human; Mouse; Rat

Recombinant Human MECP2 protein

BMP; MECP; MRXS; DKFZp686A; Methyl-CpG-binding protein; AUTSX; MRX; MECP2; AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; DKFZp686A24160; MeCp-2 protein; Methyl-CpG-binding protein 2; BMP7; OP1; AUTSX 3; Mbd 5; Mbd5; MECP 2; MeCP 2 protein; Methyl CpG binding protein 2; Methyl CpG binding protein 2 (Rett syndrome) ; MRX 16; MRX 79; MRXS 13; WBP 10; WBP10

6A1

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling; Neuroscience

Protein A

0.2 mg/mL

IHC 1:200-1:1000; WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/vsGCz2bI

52 kDa

75 kDa

IgG, κ