Recombinatie MEK5 monoklonaal antilichaam

MEK5 is a dual specific kinase that specifically activates ERK5 involved in the regulation of diverse cellular processes, including cell growth, survival, and differentiation. The MEK5-ERK5 pathway is activated in numerous cancer types and plays a role in tumor growth and metastasis. Pharmacological targeting of the MEK5-ERK5 pathway has been investigated as a strategy for cancer treatment. MEK5 is activated by a variety of stimuli, including growth factors, cytokines, and oxidative stress. Activation of MEK5 is triggered by upstream kinases MEKK2 and MEKK3, leading to phosphorylation of MEK5 at Ser311 and Thr315, which subsequently leads to MEK5 dependent phosphorylation of EKR5 at Thr218 and Tyr220. Phosphorylation of ERK5 leads to nuclear translocation and regulation of several oncogenic transcription factors, including MEF2C, c-Fos, c-Myc, and Sap1.

MEK5

Q13163

Human

Recombinant human MEK5 fragment

MEK; MKK; MAP2K; MAPKK; PRKMK; MAP2K5; HsT17454; MAPKK5; MEK5; PRKMK5; MKK5; Dual specificity mitogen activated protein kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5; EC 2.7.12.2; kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MEK 5; mitogen-activated; mitogen-activated protein kinase kinase 5; MP2K5; Protein kinase; SAPKK5; SKK5

A623

Unconjugated

WB

Signal Transduction; Cancer; Cardiovascular

Protein A purified

1 mg/mL

WB 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/412NT2LV

49, 50 kDa

49, 50 kDa

IgG, κ