Recombinatie MYH7 monoklonaal antilichaam

Nonmuscle myosin is an actin-based motor protein essential to cell motility, cell division, migration, adhesion, and polarity. The holoenzyme consists of two identical heavy chains and two sets of light chains. The light chains (MLCs) regulate myosin II activity and stability. The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10, and MYH14, which generate three different nonmuscle myosin II isoforms, IIa, IIb, and IIc, respectively. While all three isoforms perform the same enzymatic tasks, binding to and contracting actin filaments coupled to ATPhydrolysis, their cellular functions do not appear to be redundant and they have different subcellular distributions. The carboxy-terminal taildomain of myosin II is important in isoform-specific subcellular localization. Research studies have shown that phosphorylation of myosin IIa at Ser1943 contributes to the regulation of breast cancer cell migration.

MYH7

P12883

Human; Rat; Mouse

Peptide. This information is proprietary to PTMab.

CMH; MPD; MYH; myosin; MYH7; CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM; myosin-7; PVALB

A707

Unconjugated

IHC

Signal Transduction; Stem Cells; Cardiovascular; Developmental Biology; Immunology

Protein A purified

1 mg/mL

IHC 1:1000-1:2000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/UerfZ5U0

IgG, κ