Recombinatie Neutrofiel Elastase monoklonaal antilichaam

Neutrophil Elastase is hematopoietic serine protease that belongs to the chymotrypsin superfamily and plays a critical role in the innate immune function of mature neutrophils and monocytes. Neutrophil elastase is actively synthesized as an inactive zymogen in myelocytic precursor cells of the bone marrow, which then undergoes activation by limited proteolysis and sorting to primary (azurophil) storage granules of mature neutrophil granulocytes for regulated release. Research studies have shown that neutrophils play a significant role in mediating the inflammatory response through the release of neutrophil elastase, which activates pro-inflammatory cytokines and degrades components of the extracellular matrix and Gram-negative bacteria. Mutations in the gene encoding neutrophil elastase, ELA2, have been implicated in hematological diseases such as cyclic and severe congenital neutropenia, which is characterized by defects in promyelocyte maturation.

Neutrophil Elastase

P08246

Human

Recombinant human Neutrophil Elastase fragment

SCN; ELA; Elastase; ELANE; ELA2; GE; HLE; HNE; NE; PMN-E; SCN1; Elastase-2; Medullasin; Neutrophil elastase; Bone marrow serine protease; Human leukocyte elastase; PMN elastase; Elastase 2; Elastase 2 neutrophil; Elastase neutrophil expressed; ELNE; Granulocyte derived elastase; Leukocyte elastase; Neutrophil expressed; PMN E; Polymorphonuclear elastase

A585

Unconjugated

WB

Immunology; Microbiology; Signal Transduction; Cancer; Kits; Lysates; Other

Protein A purified

1 mg/mL

WB 1:1000-1:5000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/lIZAvZ4b

29 kDa

29 kDa

IgG, κ