Recombinatie p21 monoklonaal antilichaam

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation.

P21

P39689

Mouse; Rat

Recombinant Mouse p21 protein

Cip; Waf; Cip1; Waf1; Cdkn1a; CAP20; CDKN1; cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1A; MDA-6; P21; PIC1; SDI1

2D12

Unconjugated

WB

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/qM1wVUj0

18 kDa

18 kDa

IgG, κ