Recombinatie p21 monoklonaal antilichaam

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

P21

P38936

Human; Rat

Recombinant Human p21 protein

WAF; SDI; CIP; CAP; PIC; CDKN; CDK-interacting protein; cyclin-dependent kinase inhibitor; Melanoma differentiation-associated protein; p21CIP; Slc12a; MDA; CDKN1A; CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1; cyclin-dependent kinase inhibitor 1; CDKI; CDK-interacting protein 1; CDN1A; Cyclin Dependent Kinase Inhibitor 1A; DNA Synthesis Inhibitor; Melanoma differentiation-associated protein 6; P21waf; SLC12A9; FASN; FAS; MDA6; PIC1; CAP20; CDKN1; CIP1; cyclin-dependent kinase inhibitor 1; MDA-6; P21; p21CIP1; SDI1; WAF1; cyclin-dependent kinase inhibitor 1A

5A2

Unconjugated

WB; IHC

Cell Biology; Epigenetics and Nuclear Signaling; Cancer; Kits; Lysates; Other

Protein A

0.2 mg/mL

IHC 1:100-1:200; WB 1:1000-1:5000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/r83ytOyG

18 kDa

18 kDa

IgG, κ