Recombinatie PDK1 monoklonaal antilichaam

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

PDK1

Q15118

Human; Mouse

Recombinant human PDK1 fragment

PDK; PDHK; PDK1; PDHK1

A325

Unconjugated

IHC; IF

Signal Transduction; Cancer; Metabolism

Protein A purified

1 mg/mL

IHC 1:100; IF 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/DytE46ll

IgG, κ