Recombinatie PKT1B monoklonaal antilichaam

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family and PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

PTP1B

P18031

Human; Rat; Mouse

Recombinant human PTP1B fragment

PTPN; PTPN1; PTP1B

A510

Unconjugated

WB; IHC; IF

Signal Transduction; Cardiovascular

Protein A purified

1 mg/mL

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/l2dxBo8w

50 kDa

50 kDa

IgG, κ