Recombinatie PLCG1 monoklonaal antilichaam

Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling.In response to extracellular stimuli, such as hormones, growth factors, and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) . At least four families of PLCs have been identified: PLCβ, PLCγ, PLCδ, and PLCε. Phosphorylation is one of the key mechanisms that regulate the activity of PLC. PLCγ is activated by both receptor and non-receptor tyrosine kinases. PLCγ forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCγ at Tyr771, 783, and 1248. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCγ1. PLCγ2 is engaged in antigen dependent signaling in B cells and collagen-dependent signaling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197, and 1217 is correlated with PLCγ2 activity.

PLCG1

P19174

Human; Rat; Mouse

Peptide. This information is proprietary to PTMab.

PLCG; phospholipase C gamma; NCKAP; PLCgamma; PLC; PLCG1; NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1; phospholipase C gamma 1; NCKAP3; phospholipase C gamma 1; PLC1; PLC148; PLCgamma1; PLC-II

A717

Unconjugated

WB

Cardiovascular; Signal Transduction; Cancer; Metabolism

Protein A purified

1 mg/mL

WB 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/TF87imvP

149 kDa

150 kDa

IgG, κ