Recombinatie PRAS40 monoklonaal antilichaam

PRAS40 is a proline-rich protein with a molecular weight of 40 kDa that acts as a substrate for the serine / threonine kinase Akt. PRAS40 also binds mTOR to transduce Akt signals to the mTOR complex. Inhibition of mTOR signaling stimulates PRAS40 binding to mTOR, which in turn inhibits mTOR activity. PRAS40 interacts with raptor in mTOR complex 1 (mTORC1) in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183.

PRAS40

Q96B36

Human; Rat; Mouse

Recombinant human PRAS40 fragment

PRAS; AKT1 substrate; AKT1S; AKT1S1; Lobe; PRAS40; AKT1 substrate 1

A589

Unconjugated

WB; IHC

Cell Biology; Neuroscience; Signal Transduction

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:50-1:200

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/fkg7rc6T

27 kDa

40 kDa

IgG, κ