Recombinatie QKI monoklonaal antilichaam

QKI is a member of the signal transduction and activator of RNA (STAR) protein family of RNA-binding proteins. Mutations in the mouse Qki locus results in impaired myelin formation resulting in tremors. QKI proteins exist as homodimers, and disruption of the dimerization process is lethal in mice. QKI exists in different isoforms that differ in their C-terminus, resulting in unique subcellular localizations. The nuclear isoform of QKI, QKI-5, is involved in regulation of alternative splicing of MAG mRNA, which encodes for a protein important for myelin sheath formation and maintenance. QKI has also been implicated in schizophrenia and oligodendrocyte differentiation. QKI can function as a tumor suppressor, as it is regulated by p53 to stabilize miRNAs that regulate TGF-β signaling.

QKI

Q96PU8

Human; Rat; Mouse

Recombinant human QKI fragment

QKI; Hqk; QK; QK1; QK3; hqkI; HKQ

A575

Unconjugated

WB; IF

Neuroscience; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:500-1:3000; IF 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/44JVPLWz

38 kDa

38 kDa

IgG, κ