Recombinatie Rb monoklonaal antilichaam

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Rb

P06400

Human; Mouse

Recombinant Human Rb protein

PPP1R; OSRC; PPP1R130; RB; p105-Rb; pRb; pp110; RB1; Exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; Osteosarcoma; P105RB; PP105; Prepro retinoblastoma associated protein; Protein phosphatase 1 regulatory subunit 130; RB transcriptional corepressor 1; RB1 gene; retinoblastoma 1; Retinoblastoma protein; Retinoblastoma suspectibility protein; Retinoblastoma-associated protein

10A10

Unconjugated

WB

Cell Biology; Epigenetics and Nuclear Signaling; Cancer

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/YSlIBJAO

106 kDa

110 kDa

IgG, κ