Recombinatie ROCK1 monoklonaal antilichaam

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

ROCK1

Q13464

Human; Mouse; Rat

Recombinant Human ROCK1 protein

ROCK; ROCK1; P160ROCK; ROCK-I

12B7

Unconjugated

WB; IHC

Signal Transduction; Cell Biology; Cancer

Protein A

0.2 mg/mL

IHC 1:200-1:1000; WB 1:1000-1:5000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/JTAokoSl

158 kDa

158 kDa

IgG, κ