Recombinatie RUNX3- monoklonaal antilichaam

RUNX3 is a member of the Runt family of transcription factors, playing an important role in the suppression of gastric epithelium cell proliferation, dorsal root ganglia neurogenesis, and T cell differentiation. RUNX3 is also involved in Caspase-3-dependent apoptosis. Protein complexes containing RUNX3 and various transcription factors, such as Smads or β-catenin/TCF4, have tumor suppressor activity and regulate downstream target gene transcription. While typically localized to the nucleus, RUNX3 can be tyrosine phosphorylated and located in the cytoplasm of many cancer cells. This mislocalization of RUNX3 abolishes its tumor suppressor function and contributes to tumorigenesis.

RUNX3

Q13761

Human

Recombinant human RUNX3 fragment

AML; RUNX; CBFA; Oncogene AML; Core-binding factor subunit alpha; Runt-related transcription factor; PEBP2A; RUNX3; AML2; CBFA3; PEBP2aC; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; Oncogene AML-2; Runt-related transcription factor 3; PEBP2A3

A518

Unconjugated

WB; IP

Epigenetics and Nuclear Signaling; Neuroscience; Stem Cells; Cancer; Developmental Biology

Protein A purified

1 mg/mL

WB 1:500-1:1000; IP 1:25-1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/uwQ95J0q

46 kDa

44-46 kDa

IgG, κ