Recombinatie Serpind1 / HCII monoklonaal antilichaam

SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans (GAG) . The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

SerpinD1

P49182

Mouse

Recombinant Mouse SerpinD1 protein

Hcf; Heparin cofactor; Protease inhibitor leuserpin; SERPIND; Serpin D; HC-II; Heparin cofactor 2; Heparin cofactor II; Protease inhibitor leuserpin-2; Serpin D1; Hcf2; Hcii; Serpind1; HC II; HC2; HLS2; LS2; Serpin Peptidase Inhibitor Clade D Member 1; THPH10

5C1

Unconjugated

WB; IP

Protein A

1 mg/mL

WB 1:500-1:1000; IP 0.2-1 μL/mg of lysate

0.2 μm filtered solution in PBS

Ice bag

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

https://789.bio/eb/w79Uplfk

57 kDa

53 kDa

IgG