Recombinatie SF3B3 monoklonaal antilichaam

SF3B3 is one of four proteins for SF3B, which is involved in RNA splicing. Introns are removed from nuclear pre-mRNA in 2-step transesterification reactions. Splicing occurred in a large ribonucleoprotein particle, called the spliceosome. Spliceosomal intermediate complexes form on pre-mRNA in the order E, A, B, and C, with the catalytic reactions occurring in complex C. U2 small nuclear ribonucleoproteins are one of the proteins essential for spliceosome assembly and mRNA splicing. Functional U2 snRNP is composed of a 12S unit and 2 splicing factors, SF3A, which is composed of 3 proteins, and SF3B, which composed of 4 proteins. SF3B3 is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.

SF3B3

Q15393

Human; Rat; Mouse

Recombinant human SF3B3 fragment

SAP; SF3B; KIAA; Splicing factor 3B subunit; Spliceosome-associated protein; Spliceosome-associated protein 130; Splicing factor 3B subunit 3; SF3B3; KIAA0017; SAP130; Pre mRNA splicing factor SF3b 130 kDa subunit; Pre-mRNA-splicing factor SF3b 130 kDa subunit; RSE1; SAP 130; SF3b130; SF3B3_HUMAN; Spliceosome associated protein 130; Splicing factor 3b subunit 3 130kD; STAF130

A553

Unconjugated

WB; IHC; IP

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:500-1:2000; IP 1:25

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/82HdhasP

135 kDa

135 kDa

IgG, κ