Recombinatie SIRT6 monoklonaal antilichaam
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway.
SIRT6
Q8N6T7
• Rabbit
Human; Rat; Mouse
Recombinant human SIRT6 fragment
SIRT; SIR2L; sirtuin; SIR2L6; SIRT6; sirtuin 6
• Monoclonal
• Recombinant
A547
Unconjugated
WB
Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism
Protein A purified
1 mg/mL
WB 1:500-1:1000
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Ice bag
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
https://789.bio/eb/h4ilvZTT
39 kDa
42 kDa
IgG, κ
Beschrijving
Recombinatie SIRT6 monoklonaal antilichaam Beschikbaar in 50 µL. Bestel eenvoudig online met snelle levering.
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