Recombinatie Smac / Diablo monoklonaal antilichaam

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) . Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Smac/Diablo

Q9NR28

Human; Rat; Mouse

Recombinant human Smac/Diablo fragment

DFNA; DIABLO; DFNA64; SMAC;0610041G12Rik; DBLOH; DBOH; Diablo homolog; Diablo homolog (Drosophila) ; Diablo homolog mitochondrial; Diablo IAP binding mitochondrial protein; Diablo like protein; DIABLO S; Direct IAP binding protein with low pI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; mitochondrial; Mitochondrial Smac protein; Second mitochondria derived activator of caspase; Second mitochondria-derived activator of caspase; SMAC 3; Smac protein; SMAC3

A361

Unconjugated

WB; IHC; IF; FCM; IP

Cell Biology; Cancer; Metabolism

Protein A purified

1 mg/mL

WB 1:500-1:2000; IHC 1:50-1:100; IF 1:500-1:1000; FCM 1:50-1:100; IP 1:25-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/KjTyuxHd

27 kDa

21 kDa

IgG, κ