Recombinatie SMARCC2 / BAF170 monoklonaal antilichaam

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) .Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by alteringDNA-histone contacts within a nucleosome in an ATP-dependent manner. BAF170 is one of the core subunits of the SWI/SNF complex, which is necessary for efficient nucleosome remodeling by Brg1 in vitro. While BAF170 has been shown to be part of the SWI/SNF complexin non-pluripotent cells, it is absent in pluripotent embryonic stem (ES) cells. Research studies have shown that expression of BAF170 is upregulated in neurons/neuronal progenitors upon differentiation of mouse ES cells with retinoic acid, and exogenous expression of BAF170leads to loss of stem cell pluripotency and self renewal.

SMARCC2/BAF170

Q8TAQ2

Human; Mouse

Peptide. This information is proprietary to PTMab.

Rsc; BAF; CRACC; SMARCC; SMARCC2; BAF170; CRACC2; Rsc8

A785

Unconjugated

WB; IHC; FCM; IP

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:1000-1:2000; IHC 1:500-1:1000; FCM 1:100; IP 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/gyyXfR38

133 kDa

170 kDa

IgG, κ