Recombinatie SMC1A monoklonaal antilichaam

He cohesin complex consists of a heterodimer between SMC1 (SMC1A or B) and SMC3, bound by additional RAD21 and STAG proteins (STAG1, 2, or 3) . These proteins form a ring-like structure that mediates the cohesion of two sister chromatids after DNA replication in S phase. RAD21 and STAG2 are phosphorylated by Polo-like kinase (PLK) during prophase, which leads to the dissociation of cohesin complexes from the chromosome arms; however, cohesin remains bound to centromeres until anaphase. RAD21 is cleaved by separin/ESPL1 in anaphase, which leads to dissociation of the remaining cohesin from centromeres, enabling sister chromatids to segregate during mitosis. RAD21 is also cleaved by caspase-3 and caspase-7 during apoptosis, resulting in a 64 kDa carboxy-terminal cleavage product that translocates to the cytoplasm and may help to trigger apoptosis. In addition to mediating cohesion of sister chromatids, the cohesin complex plays important roles in gene regulation and DNA repair, as SMC1 and SMC3 are both phosphorylated by ATM and ATR kinases upon DNA damage.

SMC1A

Q14683

Human; Mouse

Peptide. This information is proprietary to PTMab.

SMC; CDLS; KIAA; SMC1L; SMC1A; CDLS2; DXS423E; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB; KIAA0178; Chromosome segregation protein SmcB; MGC138332; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC1 (structural maintenance of chromosomes 1 yeast) like 1; SMC1 structural maintenance of chromosomes 1 like 1; SMC-1A; SMC-1-alpha; Structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A

A706

Unconjugated

WB

Cell Biology; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:1000-1:2000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/83k4HxRa

141 kDa

160 kDa

IgG, κ