Recombinatie SP1 monoklonaal antilichaam

Specificity protein 1 (SP1) is a ubiquitously expressed transcription factor belonging to the family of C2H2-type zinc finger containing DNA-binding proteins. SP1 binds GC-rich motifs with high affinity and regulates the expression of numerous mammalian genes. It interacts with many other transcription factors, such as c-Myc, EGR1, and Stat1, and with basal transcription machinery components. SP1 interacts with chromatin-modifying factors, such as histone deacetylases (HDACs) and p300 in chromatin remodeling. Transcriptional activity and stability of SP1 are regulated by post-translational modification, including phosphorylation, acetylation, ubiquitination, and glycosylation. Glycosylation of SP1 following insulin treatment leads to increased nuclear localization, while glucagon treatment increases cytoplasmic SP1 levels. Investigators have found high levels of SP1 in patients with Alzheimer's disease.

SP1

P08047

Human; Rat; Mouse

Recombinant human SP1 fragment

Specificity protein; Transcription factor Sp; SP1; SP 1; Sp1 transcription factor; Specificity protein 1; Transcription factor Sp1; TSFP 1; TSFP1

A682

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling; Stem Cells; Metabolism

Protein A purified

1 mg/mL

WB 1:1000; IHC 1:50

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/6Cz0aRgi

81 kDa

100 kDa

IgG, κ